The Study on Methylation of hMLH1 Gene in Sporadic Colorectal ...

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Tumor Research

[Abstract]

Purpose: To investigate the action of CPG island methylation of hMLH1 in sporadic colorectal cancer and to study the relationship between hMLH1 methylation and clinical informationMethods: We use Methylation specific PCR(MSP)to study the methylation o hMLH1 in 40 cases of sporadic colorectal tumor ,21case of colorectal adenomas and 14 normal colorectal mucosaResults: there were 23 cases be detected methylation of hMLH1 gene promoter among 40 colorectal cancer(57.5%);4 cases happened methylation among 21 cases colorectal adenomas(19%).And there was no cases happened methylation in normal cases .The rate of hMLH1 methylation in sporadic colorectal cancer significantly higher than colorectal adenoma and normal mucosa.(P

Title: The Study on Methylation of hMLH1 Gene in Sporadic Colorectal Cancer

Category: Tumor Immunology

Filename: The Study on Methylation of hMLH1 Gene in Sporadic Colorectal Cancer.pdf

Pages: 164

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